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在内镜下粘膜切割后早期胃心脏癌症的预后模型

Peng Zhang¹, Xiaoying Ma², Zibin Tian¹

¹Department of Gastroenterology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao City, Shandong Province, 266000, China.

|November 1, 2025

概括

使用microRNA-1246,HMGB-1,A1AT和炎症标记物的新预后模型预测了内镜下膜剖析 (ESD) 后早期胃心脏癌症患者的结果. 这个工具有助于个性化风险评估治疗后.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
胃肠病学胃肠病学

背景情况:

早期胃心脏癌症 (EGCC) 需要有效的预后工具,即内镜后的粘膜下剖析 (ESD).
目前的方法可能无法完全捕捉EGCC预后的复杂性.
识别可靠的生物标志物对于个性化患者管理至关重要.

研究的目的:

开发和验证一种预后模型,用于预测EGCC患者在ESD后的预后结果.
为了将microRNA-1246 (miR-1246),高流动性组框1 (HMGB-1),α1-抗素 (A1AT) 和炎症标志物纳入模型.
评估模型的预测性能和临床实用性.

主要方法:

对280名接受ESD的EGCC患者进行了回顾性分析.
分为培训 (n=196) 和验证 (n=84) 队列.
后勤回归,LASSO分析,名图构造,ROC曲线,校准曲线和DCA用于模型评估.

主要成果:

多变量分析确定了miR-1246,HMGB-1,A1AT,TNF-α和H. pylori感染作为预后不佳的独立风险因素.
诺米图表显示出良好的区分能力 (AUC 0.789培训,0.735验证).
校准曲线证实了预测和观察结果之间的良好一致性.

结论:

开发的预后模型为EGCC患者在ESD后的个性化风险评估提供了一个实用的工具.
建议在大型多中心前性研究中进一步验证临床应用.

关键词:

早期的胃心脏癌症是什么内镜下粘膜切割进行内镜下粘膜切割.高流动性小组第1框高流动性小组第1框微型RNA-1246是什么意思预测模型是一个预测模型.一个α1-抗素.

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