化石墨烯改性生物丁:对其离子释放,细胞生长,分化潜力和压力强度进行了体外研究
Fagr Hassan Elmergawy1, Iman Ahmed Fathy2, Zeinab Mahmoud Abulwafa3
1Lecturer of Dental Biomaterials, Faculty of Dentistry, October University for Modern Sciences and Arts (MSA), 26th July Mehwar road intersection with Wahat road, 6th October City, Egypt. fmergawy@msa.edu.eg.
BMC oral health
|November 1, 2025
概括
将化石墨烯 (FG) 添加到生物牙 (BD) 中,可以提高其生物活性和机械强度. 这种修改后的Biodentine显示出更好的离子释放和压力强度,而不会对细胞活力产生负面影响.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 纳米技术纳米技术
背景情况:
- 生物牙 (Biodentine,简称BD) 是一种基于酸的材料,用于牙科.
- 基于石墨烯的材料为生物材料应用提供了独特的特性.
- 化石墨烯 (FG) 已经显示出增强材料特性的潜力.
研究的目的:
- 评估将2%重量的化石墨烯 (FG) 纳入生物牙 (BD) 的效果.
- 评估FG修改对BD物理,化学和生物特性的影响.
主要方法:
- FG是使用修改后的汉默斯方法合成的.
- 描述包括XRD,FTIR,TEM,以及SEM/EDX.
- 评估pH值,离子释放 (Ca,F),细胞活力 (MTT测定),ALP活性和压力强度.
主要成果:
- 结合FG增加了BD的表面粗度,pH值和离子释放.
- 早期细胞活力没有显著差异,但在BD-FG的第3天是较低的.
- 在BD-FG中,压力强度显著提高,ALP活性相当.
结论:
- 将2重%的FG纳入BD中可以增强离子释放和机械性能.
- 修改后的BD-FG显示了改善的生物活性和强度,没有显著的细胞毒性.
- 修改FG是一种有前途的方法来提高Biodentine的性能.
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