西班牙的初级侧面硬化功能评级表 (PLSFRS) 的西班牙改编
Alejandro Caravaca Puchades1,2,3, Mònica Povedano Panadés1, María Bea Sintes4
1Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL (Institut d'Investigació Biomèdica de Bellvitge), University of Barcelona, Barcelona, Spain.
Amyotrophic lateral sclerosis & frontotemporal degeneration
|November 1, 2025
概括
西班牙语版本的原发性侧面硬化功能评级表 (PLSFRS) 是可靠的,用于评估原发性侧面硬化 (PLS) 患者的疾病进展. 这种经过验证的工具有助于对这种罕见的神经退行性疾病的临床试验.
科学领域:
- 神经学 神经学
- 临床评估工具 临床评估工具
背景情况:
- 初级侧面硬化 (PLS) 是一种进展性神经退行性疾病,缺乏有效的治疗方法.
- 需要一个特定的评估工具来促进PLS的临床试验.
研究的目的:
- 将主要侧面硬化功能评分表 (PLSFRS) 翻译成西班牙语并验证.
- 确定西班牙PLSFRS用于评估PLS进展的可靠性.
主要方法:
- PLSFRS被翻译成西班牙语和反译.
- 十名PLS患者被两个独立的评价者通过面对面和电话采访进行评估.
- 评估了评估者间和内部的可靠性,以及评估方法之间的一致性.
主要成果:
- 西班牙的PLSFRS表现出极好的inter-和intrarater可靠性 (ICC = 0.90-1.00).
- 临床和电话评估之间的一致性很强.
- 布兰德-阿尔特曼分析显示没有显著的系统偏差.
结论:
- 西班牙语版本的PLSFRS是评估初级侧面硬化症患者的可靠工具.
- 这种经过验证的尺度可以支持未来的临床试验和研究在西班牙语PLS群体.
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