牙周炎和牙周病的口腔微生物群签名 - 一项基于人口的研究
Preethi Balan1,2, Fabio R M Leite1,2,3, John Rong Hao Tay4,5
1National Dental Research Institute Singapore, National Dental Centre Singapore, Singapore City, Singapore.
Journal of periodontal research
|November 1, 2025
概括
口腔微生物群的多样性随着牙周炎的严重程度而发生变化,牙周病症的减少. 关键的细菌属发生变化,对牙科植入物有影响.
科学领域:
- 口腔微生物学 口腔微生物学
- 牙周病学 牙周病学
- 微生物组的分析
背景情况:
- 牙周炎是一种常见的炎症性疾病,影响牙支结构.
- 牙病或牙脱落是未经治疗的口腔疾病的严重后果.
- 口腔微生物组在保持口腔健康方面发挥着至关重要的作用.
研究的目的:
- 研究口腔微生物组,牙周炎和牙周病之间的关系.
- 分析细菌的多样性和组成与牙周炎的严重程度和牙损失有关.
- 为了确定与牙周炎和牙炎相关的特定细菌种群.
主要方法:
- 使用NHANES 2009-2012数据对5299名美国成年人的分析.
- 在口腔冲洗样本中的16S rRNA基因测序.
- 使用2017年AAP/EFP分类和ACES框架对牙周炎的评估.
- 使用多变量模型评估细菌多样性 (α和β) 和分类组合.
主要成果:
- 阿尔法多样性随着牙周炎的严重程度增加而增加,但随着广泛的牙损失和牙周病症而减少.
- 在牙周炎各个阶段观察到β多样性的微妙差异.
- 牙周炎与像Porphyromonas和Prevotella这样的属的丰富和Rothia的枯竭有关.
- 在没有牙的个体和严重的牙周炎病例中,13个属被常见地改变.
结论:
- 口腔微生物组的α多样性遵循一个U形曲线,牙周炎的进展和牙周病.
- 分类学转变涉及特定的牙周炎相关细菌和Jonquetella.
- 这些细菌在没有牙的个体中持续存在,对植入式牙科有影响.
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