动脉硬与老化中的前额叶皮层完整性有关
Rachael Yu1,2, Nicole Espinosa3,4, Shawn Kong3,4
1Healthy Brain Ageing Program, Brain and Mind Centre, School of Psychology, Faculty of Science, University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia. rachael.yu@sydney.edu.au.
GeroScience
|November 1, 2025
概括
通过脉冲波速度 (PWV) 测量的动脉硬度与老年人前额叶皮层厚度的减少有关. 这表明动脉硬化可能是脑部变化和认知衰退的可修改风险因素.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 动脉硬,用脉冲波速度 (PWV) 量化,与认知衰退和痴呆症有关.
- 受动脉硬影响的特定大脑结构仍然不完全理解.
- 前额叶皮质 (PFC) 对认知功能至关重要,可能容易受到血管变化的影响.
研究的目的:
- 调查脉冲波速度 (PWV) 与前额叶皮层 (PFC) 的皮质厚度之间的关联.
- 为了探索动脉硬和结构性大脑变化之间的关系,在认知问题老年人的老年人.
主要方法:
- 124名老年人 (>50岁) 患有新出现的认知问题,接受了带关PWV和MRI扫描.
- 使用FastSurfer估计了中间,侧面和总PFC的皮层厚度.
- 进行了神经心理评估,并根据年龄,性别和心血管因素调整了分析.
主要成果:
- 较高的PWV与总PFC (r=-.290,pFDR=.014),特别是左半球 (r=-.338,pFDR=.008) 的缩小厚度显著相关.
- 观察到PWV与左侧中间PFC (r=-.238,pFDR=.014) 和所有横向PFC区域的减少厚度之间存在显著的关联.
- 这些关联在调整年龄,性别和传统心血管风险因素后仍然存在.
结论:
- 这项研究提供了第一个证据,将较高的PWV与老年人PFC皮质厚度的降低联系在一起,独立于传统的心血管风险因素.
- 动脉硬化成为潜在的可修改风险因素,有助于衰老中神经退行性和结构性大脑变化.
- 减少PFC厚度和增加PWV都与较差的执行功能有关,突出显示了血管健康对大脑衰老的临床相关性.
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