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肠道微生物组的特征预测了老年癌症幸存者的认知障碍

Brandi C Miller^1,2,3, Jayden A Haggler^1,2,3, Diptaraj S Chaudhari^1,2,3

¹USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

|November 1, 2025

概括

癌症幸存者经常因肠道微生物组变化而面临认知障碍. 特定的细菌和肠道中耗尽的神经递质合成可能预测癌症生存率和认知能力下降风险.

科学领域:

微生物组研究的研究.
癌症的生存率癌症的生存率
认知健康认知健康

背景情况:

癌症治疗正在增加幸存者数量,但导致长期副作用,如认知障碍 (CI).
人们已经认识到肠道微生物组在认知健康中的作用,但其对癌症后治疗的长期影响尚不清楚.
了解这些微生物组变化对于改善癌症幸存者的生活质量至关重要.

研究的目的:

研究癌症治疗对肠道微生物群的长期影响.
为了确定微生物群签名是否可以区分癌症幸存者和预测认知障碍风险.
探索可能的机制,将肠道微生物组的改变与老年人中的CI联系起来.

主要方法:

从150名老年人 (49名癌症幸存者,101名对照者) 的便样本中进行了枪支元基因组测序.
对微生物组合和代谢途径的分析.
微生物特征与癌症生存状况和认知障碍的相关性.

主要成果:

特定的肠道细菌 (Tyzzerella,Eggerthella lenta,Bacteroides vulgatus) 被确定为癌症幸存者的标记物.
在CI的癌症幸存者中与没有癌症和CI的非癌症个体相比,发现了明显的微生物组特征.
在幸存者中,降低了与CI相关的Streptococcus thermophilus和Firmicutes细菌CAG 114的水平;微生物神经递质合成被耗尽.

结论:

肠道微生物组的特征可以预测癌症的生存率和老年人认知障碍的风险.
肠道中微生物神经递质合成的枯竭可能是癌症治疗,微生物组变化和CI之间的关键机制.
这些发现支持微生物组在癌症生存结果中的作用,并为新的治疗干预提供了潜在的目标.

关键词:

衰老的衰老衰老的衰老脑子脑子脑子脑子癌症癌症癌症癌症认知认知是一种认知.这是一个很棒的体验,Gut Gut Gut Gut.微生物组是一个微生物组.

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