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Updated: Jul 28, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

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通过激活 GCN2 途径来实现小鼠 T 细胞的 halofuginone 中介代谢重编程的协议

Meghan Kates1, Michael St Paul1, Pamela S Ohashi1

  • 1Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada.

STAR protocols
|November 1, 2025
PubMed
概括

本研究详细介绍了一种使用halofuginone在小鼠T细胞中激活一般控制非抑郁性2 (GCN2) 途径的协议. 这种方法提高了T细胞在癌症采用细胞治疗中的疗效.

关键词:
细胞生物学 细胞生物学细胞隔离细胞的隔离.免疫学 免疫学 免疫学代谢过程中的代谢.

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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo08:19

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相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.