多发性硬化和与炎症性肠病的关联:从回顾性队列研究的结果
Parisa Karimi1, Chunshen Pan1, Magdalena Chirieac2
1Patient Safety and Pharmacovigilance, Morristown, NJ, USA.
Multiple sclerosis and related disorders
|November 1, 2025
概括
与没有多发性硬化症 (MS) 的患者相比,多发性硬化症患者的炎症性肠病 (IBD) 发病率明显高. 这项研究强调了MS和IBD风险增加之间的潜在联系.
科学领域:
- 胃肠病学 胃肠病学
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 炎症性肠病 (IBD) 涵盖了胃肠道的慢性炎症状况,包括性结肠炎和克罗恩病.
- 多发性硬化和IBD之间的潜在关联需要进一步调查,以了解共享的风险因素和疾病机制.
研究的目的:
- 在被诊断为多发性硬化症 (MS) 的患者中调查和比较炎症性肠病 (IBD) 的发病率 (IRs).
- 为了比较患有多发性硬化症的患者与无多发性硬化症患者的匹配队列之间的IBD发病率.
- 确定MS和IBD发展之间的潜在关联.
主要方法:
- 使用Optum Clinformatics® Data Mart数据库 (Optum® CDM) 采用了回顾性队列研究设计.
- 在2008年1月1日至2022年12月31日期间,使用ICD-9/10诊断码识别了MS患者和匹配的对照 (1:5比例基于年龄,性别和入学年份).
- 计算了IBD的发病率,并将MS队列和对照组进行了比较,并对潜在的混因素进行了调整.
主要成果:
- 该研究确定了27794名患有多发性硬化症的患者和138970名匹配的对照.
- 在患有多发性硬化症的患者中,IBD的发病率较高 (每1000人年25.54例),相比于匹配的对照组 (每1000人年14.58例).
- 与对照组相比,MS患者的IBD调整发病率是IBD的1.45倍,这表明统计学上显著的风险增加.
结论:
- 患有多发性硬化症的患者表现出明显更高的炎症性肠病发病率.
- 这些发现表明MS和IBD之间存在潜在的联系或共同的病因.
- 需要进一步的研究来探索导致MS患者IBD风险增加的潜在机制.
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