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与对比介质立即过敏反应相关的危险因素:系统性审查和元分析
Wenyu Huang1, Chunlei He1, Yuntian Chen1
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
European journal of radiology
|November 1, 2025
概括
女性性别是对比介质立即过敏反应 (CM-IHR) 的重要危险因素,而年龄的增加与风险的降低有关. 门诊病人的身份增加了离子对比介质反应的风险.
科学领域:
- 放射学和成像学 放射学和成像学
- 药物监督 药物监督 药物监督
- 临床过敏 临床过敏
背景情况:
- 对比剂的立即过敏反应 (CM-IHR) 是诊断成像中的一个问题.
- 识别风险因素对于患者安全和预防策略至关重要.
研究的目的:
- 进行系统审查和元分析,以确定对比剂介质立即过敏反应 (CM-IHR) 的风险因素.
主要方法:
- 在2024年12月之前对主要数据库进行系统的文献搜索.
- 对确定风险因素的95%置信区间 (CI) 的几率比率 (ORs) 的元分析.
- 使用纽卡斯尔-太华尺度进行偏差风险评估,使用希金斯I2测试进行异质性评估.
主要成果:
- 包括7项研究 (115,043名患者,736203次注射) 在内.
- 女性性别 (OR 1.46) 和对有的对比介质 (ICM-IHR) (OR 3.08) 的门诊状态是显著的风险因素.
- 增加年龄与风险呈反向关联 (OR 0.98);喘病史不显著.
结论:
- 女性性别是CM-IHR的重要风险因素,年龄增加与风险降低有关.
- 门诊病人的身份是ICM-IHR的一个风险因素.
- 之前对ICM过敏并不是一个显著的风险因素,但由于数据有限和异质性,研究结果需要谨慎解释.
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