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暴露和反社会行为:对人类和动物证据的系统审查

Rachel M Shaffer¹, Laura M Carlson¹, Kirstin Hester¹

¹Center for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC, and Research Triangle Park, NC, USA.

Environment international

|November 1, 2025

概括

暴露是与反社会行为相关的重大公共卫生问题. 这份对人类和动物研究的综述表明, (Pb) 与增加的侵略性和反社会行为之间可能存在因果关系.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
神经科学是一个神经科学.

背景情况:

(Pb) 暴露是一个持续的全球公共卫生问题.
新出现的证据将Pb暴露与反社会行为联系起来,包括侵略和行为障碍.
这项研究系统地审查了关于Pb和反社会行为的人类和动物数据.

研究的目的:

系统地审查和综合有关暴露与反社会行为的证据.
评估人类流行病学和动物毒理学数据.
为了确定Pb与反社会行为联系的强度和性质.

主要方法:

在多个数据库 (PubMed,BIOSIS,Web of Science) 搜索到2024年6月的同行评审文献.
利用机器学习进行研究选,并使用健康评估工作空间协作 (HAWC) 系统进行偏见评估.
综合了人类 (侵略,反社会诊断,社会规范) 和动物 (侵略,社会行为) 结果的证据.

主要成果:

包括43个流行病学和37个动物研究,经过广泛的查.
发现了Pb对人类和动物侵略性的轻微证据.
观察到适度的证据表明Pb与人类的反社会障碍/领域以及动物的社会行为有关.
注意到有适度的人类证据将Pb与违反社会规范的行为联系起来.

结论:

该审查表明,暴露和反社会行为之间可能存在因果关系.
跨人类和动物研究的证据综合支持这一结论.
进一步的研究可能会完善对特定机制和结果的理解.

关键词:

攻击性侵略性攻击性反社会行为反社会行为.行为障碍行为障碍.犯罪犯罪犯罪犯罪 (Pb) 是一种.神经毒性神经毒性系统性审查系统性审查

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