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增强光热疗法用于氧化还原调节的瘤亡和免疫重编程

Hongyu Chu¹, Qiong Wu², Zhonghang Xu³

¹Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China; Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China.

Acta biomaterialia

|November 1, 2025

概括

这项研究引入了一种基于的新疗法,可以选择性地向癌细胞,同时保护和激活免疫细胞. 这种双重作用可以对抗瘤,并对瘤微环境进行重新编程,以增强抗癌免疫力.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

疗对生物医学应用有希望,但其对瘤微环境 (TME) 内的免疫细胞的具体影响尚未完全理解.
选择性氧化还原调节和免疫激活对于有效的癌症治疗至关重要.

研究的目的:

开发一个载有的光热催化平台,用于TME的向氧化还原调制.
研究在TME中的癌细胞和免疫细胞中的双重作用.

主要方法:

利用-双金属 (RhPd-H) 纳米片作为近红外 (NIR) 辐射激活的输送平台.
研究了NIR触发的和热对TME中瘤细胞和免疫细胞的影响.
评估免疫细胞反应,包括树突细胞成熟,T细胞激活和巨细胞极化.

主要成果:

由NIR触发的RhPd-H纳米薄膜释放了和热量,诱导瘤细胞中的活性氧物种 (ROS) 爆发,导致亡.
作为免疫细胞中的抗氧化剂,保护它们免受氧化应激,并促进它们的抗瘤功能.
光热疗法在瘤切除和重编程免疫抑制性TME方面表现出协同效应,增强了抗瘤免疫反应.

结论:

在TME中表现出一种新的双重作用:瘤细胞中的亲氧化作用和免疫细胞中的保护/激活作用.
这种细胞上下文的氧化还原切换策略为精确的癌症治疗提供了一个范式转变.
建立了差异性氧化还原编辑作为癌症治疗的转型方法,通过整合介导的氧化还原编辑和免疫调节.

关键词:

疗法是一种疗法.免疫调节免疫调节光热疗法是一种光热疗法.雷多克斯调制的调制方法选择性的杀戮选择性的杀戮

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