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Updated: Jan 12, 2026

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HCT116细胞系异质性:临床前研究的一个有用工具

Tatyana A Grigoreva1, Aleksandra V Sagaidak1, Daria N Kindt1

  • 1Laboratory of Molecular Pharmacology, St. Petersburg State Institute of Technology (Technical University), St. Petersburg, 190013, Russia.

Chemico-biological interactions
|November 1, 2025
PubMed
概括

瘤异质性导致化疗失败. 这项研究确定了耐化学反应的癌细胞亚群,如侧面细胞群,并建议利用它们的药物敏感性来开发更有效的针对所有瘤细胞,包括干细胞的癌症治疗方法.

关键词:
癌症干细胞 (CSC) 是一种癌症干细胞.细胞分类 细胞分类化学抗药性 化学抗药性是一种抗药性.型化 (Karyotyping) 是一种方法.这是一种P-glycoprotein蛋白.罗达明 123 123 罗达明侧面人口细胞 (SP)

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A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
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