FIB-4指数的进展预测了代谢功能障碍患者的主要心血管不良事件
Francisco Idalsoaga1, Verónica Cambindo2, Eduardo Fuentes-López3
1Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Division of Gastroenterology and Hepatology, Western University & London Health Sciences Centre, London, Canada; Observatorio Multicéntrico de Enfermedades Gastrointestinales, OMEGA, Santiago, Chile.
概括
纤维化-4 (FIB-4) 评分的变化预测了代谢功能障碍患者心脏病发作风险. 升高的FIB-4表明心肌梗塞的风险更高,而降低则表明具有保护作用.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢功能障碍是与肝脏疾病和心血管疾病相关的全球健康问题.
- 对于重大心血管不良事件 (MACEs) 的非侵入性肝病严重性测试的预测价值尚不清楚.
研究的目的:
- 调查纤维化-4 (FIB-4) 评分的变化与代谢功能障碍患者的MACEs之间的关联.
主要方法:
- 一项回顾性队列研究分析了2009-2021年695名代谢功能障碍的成年患者的数据.
- 纤维化-4 (FIB-4) 评分用于评估10年随访期间的肝纤维化.
- 调整后的双项回归模型检查了FIB-4得分进展和MACEs之间的联系.
主要成果:
- 经历MACE的患者年龄较大,男性更频繁,患高血压,血脂不良和肥胖率更高.
- 在患有MACE的患者中,基线和最终FIB-4得分都升高.
- FIB-4的进展显著增加了心肌梗塞 (MI) 的风险 (RR=2.06),而FIB-4的减少显示出对MI的保护作用.
结论:
- FIB-4评分的进展与代谢功能障碍患者心肌梗塞风险增加有关.
- FIB-4评分的降低与心肌梗塞风险降低有关.
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