预防感染和传染病中的混合有效性-实施研究:叙述性综述
Lauren Clack1, Marie-Therese Schultes2, Bianca Albers3
1Institute for Implementation Science in Health Care, Faculty of Medicine, University of Zurich, Switzerland; Department of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Switzerland.
概括
混合有效性实施研究加速了感染预防和控制 (IPC) 和传染病 (ID) 的研究翻译. 标准化报告和扩大研究设置可以改善IPC/ID干预的影响.
科学领域:
- 实施科学 实施科学
- 感染预防和控制 (IPC)
- 传染病 (ID) 是一种传染病.
背景情况:
- 混合疗效实施研究结合了临床疗效和实施研究.
- 这些研究对于将研究转化为IPC和ID的实践至关重要.
- 混合研究在IPC/ID研究中的有限应用存在差距.
研究的目的:
- 审查和描述混合研究在IPC和ID研究中的使用.
- 分析混合研究中报告的干预措施,实施策略和结果.
- 确定在IPC/ID.中推进混合有效性实施研究的差距和机会.
主要方法:
- 在主要数据库 (Medline,Embase,CINAHL,Cochrane) 和Clinicaltrials.gov.gov) 进行系统的文献搜索.
- 包括研究报告和协议,评估IPC/ID干预措施在急性住院患者环境中的有效性和实施.
- 叙述性审查方法用于识别,分析和综合符合条件的混合研究的发现.
主要成果:
- 包括26项混合研究,主要来自高收入国家.
- 通常评估的有效性结果包括患者安全,服务效率和死亡率.
- 关键的实施结果是忠实性,可接受性,采用性,可行性和决定性因素;使用了多种不同的实施科学框架.
结论:
- 改进和标准化混合研究报告对于增强IPC/ID干预影响至关重要.
- 需要将混合研究扩展到不同的地理和资源环境中.
- 混合设计的更清晰的标签和更严格的方法将提高研究的可比性和现实世界的适用性.
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