接受干细胞移植的患者的能源消耗:系统性审查
Thi Nhu Ngoc Ha1, Teresa Brown2, Rachel Willims3
1School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia; Nutrition and Dietetics, Toowoomba-base Hospital, Toowoomba, Australia.
Clinical nutrition ESPEN
|November 1, 2025
概括
接受干细胞移植的患者面临营养不良的风险,原因是有限的能源供应指南. 这次审查发现,对能源支出的数据不足,特别是对移植与宿主疾病的数据不足,需要进一步研究.
科学领域:
- 血液学和瘤学研究
- 营养科学 营养科学
- 关键护理医学 关键护理医学
背景情况:
- 血造干细胞移植 (HSCT) 患者极易患有营养不良.
- 现有的临床指导方针对于高高压的能量供应是有限的.
- 移植与宿主疾病 (GvHD) 可以进一步复杂营养管理.
研究的目的:
- 系统地审查和评估HSCT患者的能量消耗 (EE).
- 为了比较HSCT患者与GvHD和没有GvHD的EE.
- 识别当前关于HSCTEE的研究中存在的差距.
主要方法:
- 在主要数据库 (PubMed,CINAHL,Embase,Cochrane,Scopus) 进行系统的文献搜索,截至2025年5月.
- 遵守PRISMA框架和使用营养和营养学学院的检查清单进行质量评估.
- 包括研究测量休息或总能量消耗在15岁以上的HSCT患者;排除案例研究,会议论文,动物和非英语研究.
主要成果:
- 十项研究符合资格标准,其中五项被评为中性质,五项被评为负性质.
- 研究中的高度异质性阻止了数据的汇集.
- 移植后的EE通常保持稳定或增加;GvHD病例与对照组相比显示同等或更高的EE.
结论:
- 对于指导HSCT患者的能量消耗,存在显著的数据缺口.
- 在HSCT和GvHD期间,密切监测营养摄入量和状态至关重要.
- 需要使用更大的样本大小和经过验证的工具进行高质量的研究,以告知临床实践.
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