大规模的大脑功能网络是非自杀性自伤行为,成和青年精神疾病中的功能基础
Xuan Liu1, Ying Yang2, Jiahui Chen1
1School of Psychology, Shandong Provincial Key Laboratory of Brain Science and Mental Health, Shandong Normal University, Jinan, 250358, China.
Journal of affective disorders
|November 1, 2025
概括
青少年的非自杀性自我伤害 (NSSI) 涉及前额-双肩,运动,边缘和基底腺网络. 这些大脑网络对于理解和治疗NSSI在各种青少年心理健康状况中至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 非自杀性自我伤害 (NSSI) 是青少年普遍存在的高风险行为,通常与严重抑郁症 (MDD) 等精神疾病同时发生.
- 在各种青少年精神障碍中,NSSI背后的特定大脑功能网络在很大程度上仍未被描述.
研究的目的:
- 识别和调查与青少年NSSI行为相关的大脑功能网络.
- 探索这些大脑网络与NSSI功能 (情绪调节,社会影响,感觉寻找) 和成特征之间的关系.
- 为了验证在独立的青少年队伍中发现的ADHD和跨诊断精神疾病的结果.
主要方法:
- 分析了156名青少年 (MDD+NSSI,MDD-NSSI,健康对照) 的功能性大脑数据.
- 太华自我伤害清单评估了NSSI行为,功能和成特征.
- 支持向量机递归特征消除用于识别预测性脑网络,在ADHD和跨诊断队列中进行外部验证.
主要成果:
- NSSI的行为主要与前额外,运动,边缘和基底细胞网络之间的互联网连接有关.
- 这些网络还与NSSI功能和成特征相关,前端-双侧网络涉及所有NSSI组件.
- 外部验证证实了这些功能网络与ADHD和跨诊断组NSSI严重程度之间的关联.
结论:
- 额头 - 双侧,运动,边缘和基底腺网络是NSSI的关键参与者,这些网络在患有精神疾病的年轻人中发挥着重要作用.
- 这些发现为NSSI预防和干预策略的潜在神经点提供了关键的见解.
- 了解这些大脑网络的贡献对于开发青少年自我伤害的有效治疗方法至关重要.
相关概念视频
Attention-Deficit/Hyperactivity Disorder
733
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
733
Functional Brain Systems: Limbic System
6.4K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
6.4K
Functional Brain Systems: Reticular Formation
4.2K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
4.2K
Brain Imaging
655
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
655
Drug Abuse and Addiction: Pharmacological Phenomena
1.1K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.1K


