血清维生素A与血B6维生素和心血管疾病风险之间的关系的变化有关
Indu Dhar1, Gard Ft Svingen2, Arve Ulvik3
1Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway; Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
The Journal of nutrition
|November 1, 2025
概括
维生素A (Vit-A) 影响维生素B6 (皮里多克萨尔5'-酸盐,PLP) 如何影响心脏病发作风险. 高维生素A水平改变了维生素B6和急性心肌梗塞 (AMI) 风险之间的关联.
科学领域:
- 营养生物化学 营养生物化学
- 心血管研究研究心血管研究
- 生物标记分析 生物标记分析
背景情况:
- 低水平的氧醇5'-酸盐 (PLP) 与心血管疾病 (CVD) 风险增加有关.
- 维生素A (Vit-A) 影响脂质平衡,并可能影响PLP运输.
研究的目的:
- 检查Vit-A是否改变了B6维生素和发生急性心肌梗塞 (AMI) 之间的关系.
主要方法:
- 考克斯回归模型被用来分析4091名接受冠状动脉血管造影的患者的数据.
- 血B6维生素 (PLP,PL,PA,PA/PL比率) 与AMI风险之间的关联是根据维生素A度进行评估的.
主要成果:
- 血PLP和PA/PL比率显示出基线关联与血清维生素A.
- 低PLP和高PA/PL比率与AMI风险增加有关,主要是在高维生素A度的患者中.
- 这些相互作用在多变量调整后仍然显著.
结论:
- 维生素B6状态与AMI风险之间的关联取决于血清维生素A水平.
- 需要进一步的研究来了解维生素A和维生素B6在动脉样硬化中的生物可用性的作用.
更多相关视频
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
542
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
542
Vitamins
2.3K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
529
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
529
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
777
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
777
Psychoneuroimmunology: Cardiovascular Disease
379
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
379
Lipid-derived Compounds in the Human Body
6.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.2K


