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Updated: Jan 12, 2026

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Studying Chronic Exposure of Mice to Ultraviolet B Radiation
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由紫外线辐射暴露引起的全身免疫抑制抑制了癌症免疫疗法
Pedro Durao1, Timothy Budden1, Karthik Mallela1
1Skin Cancer and Ageing Lab, Cancer Research UK Manchester Institute; The Oglesby Cancer Research Building, The University of Manchester, Manchester, UK.
Journal for immunotherapy of cancer
|November 1, 2025
概括
慢性紫外线辐射 (UVR) 暴露会抑制全身免疫力,降低对癌症免疫治疗的反应. 耗尽调节性T细胞 (Tregs) 恢复了治疗的有效性,建议患者避免过度暴露在阳光下.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 紫外线辐射 (UVR) 影响局部和全身免疫力,影响癌症的发展和治疗.
- 紫外线诱导的免疫抑制会影响黑色素瘤,但其对固体癌症治疗的系统性影响尚不清楚.
研究的目的:
- 为了研究反复暴露于UVR对系统免疫力的影响.
- 确定UVR如何影响癌症模型中对免疫检查点阻塞 (ICB) 的反应.
主要方法:
- 使用大肠直肠癌和黑色素瘤小鼠模型与重复的紫外线照射.
- 分析了系统性免疫细胞种群和瘤对ICB的反应.
- 研究了Treg耗尽及其对ICB反应的影响.
主要成果:
- 慢性紫外线暴露通过系统因素降低了ICB反应,扩大了调节性T细胞 (Tregs).
- 紫外线改变了全身淋巴细胞和髓状细胞群,增加了Treg透和免疫抑制.
- 在全身Treg耗尽后恢复了ICB反应;初步的人类数据显示UVR暴露与更高的Treg相关.
结论:
- 重复的紫外线暴露会诱导全身免疫抑制,阻碍癌症免疫疗法.
- 特雷格扩张是UVR诱导的免疫疗法耐药性的关键机制.
- 接受癌症免疫治疗的患者,特别是黑色素瘤患者,应避免重复暴露在阳光下.
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