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Updated: Jan 12, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Published on: November 28, 2019

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压力-NRF2反应轴使瘤巨细胞两极分化,并破坏免疫疗法

Dominik J Schaer1, Nadja Schulthess-Lutz1, Livio Baselgia1

  • 1Department of Internal Medicine, University of Zurich, Zürich, Switzerland.

Journal for immunotherapy of cancer
|November 1, 2025
PubMed
概括

转录因子NRF2驱动免疫抑制性瘤相关巨细胞 (TAMs),促进癌症生长和治疗耐药性. 抑制NRF2可以恢复抗瘤免疫力,并改善免疫治疗反应.

关键词:
免疫治疗是一种免疫疗法.巨细胞是一个巨细胞.瘤微环境 - - 瘤微环境

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