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在患有牛皮关节炎的患者中,大西洋轴下

Virginia Carrizo-Abarza¹, Fadi Kharouf², Pankti Mehta³

¹V. Carrizo-Abarza, MD, Gladman Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

The Journal of rheumatology

|November 1, 2025

概括

大西洋轴突突变 (AAS) 是牛皮关节炎 (PsA) 的不常见并发症,影响2.21%的患者. 放射性神经炎是PSA患者AAS发展的强有力的预测因素.

科学领域:

类风湿病学类风湿病学
整形外科整形外科整形外科
免疫学免疫学免疫学

背景情况:

牛皮病性关节炎 (PsA) 是一种慢性炎症性疾病,影响关节和关节.
大西洋轴突突变 (AAS) 是一种罕见的并发症,涉及上脊椎的不稳定性.
了解AAS患病率和PsA风险因素对于患者管理至关重要.

研究的目的:

为了确定AAS在PsA队列中的流行率和发病率.
为了确定与PSA中AAS相关的临床和放射性风险因素.
描述患有AAS的PsA患者的特征.

主要方法:

对1535名PsA患者的观察性队列研究,不包括创伤或宫手术患者.
计算AAS的流行率和发病率.
描述性统计,考克斯回归和概括估计方程 (GEE) 分析以确定风险因素.

主要成果:

患病率为2.21% (34/1535),每1000人年发生率为1.16.
患有AAS的患者表现出更高的放射性神经炎 (64.71%) 和外周关节损伤率.
放射性神经炎是AAS最强的预测因素 (HR 6.61),而男性性别是保护性的 (HR 0.25).

结论:

大西洋轴突突变是牛皮关节炎的一种罕见但显著的并发症.
放射性圣炎和外周关节损伤是与PSA中AAS相关的关键指标.
男性性别和年龄较大与AAS风险较低有关.

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