应用双能量计算机断层扫描到死后冠状动脉计算机断层扫描血管学
Nadia Solomon1, Matthew Hoerner2, Billy Vermillion3
1Department of Radiology and Biomedical Imaging, Yale School of Medicine, United States; Yale-Translational Research Imaging Center, Yale School of Medicine, United States; Investigative Medicine Program, Yale Graduate School of Arts and Sciences, United States.
双能量CT (DECT) 可以在死后冠状动脉CT血管学 (PMcCTA) 中区分有和加多的对比剂. 这允许在死后检查中同时评估冠状动脉通透率和心肌输液.
科学领域:
- 放射学 放射学是一门学科.
- 法医病理学 法医病理学
- 医疗成像医学成像
背景情况:
- 尸检后计算机断层扫描 (CT) 越来越多地被验尸医生使用.
- 双能量CT (DECT) 在死后成像中具有潜力,但其在死后冠状动脉CT血管学 (PMcCTA) 中的应用尚未得到研究.
研究的目的:
- 评估DECT是否可以在PMcCTA后区分两种具有不同性质的对比剂.
- 评估DECT在冠状动脉通透性和心肌 perfusion 的同时表征方面的能力.
主要方法:
- 使用和加多对比剂的幻影用DECT进行了成像.
- 活体猪心经历了PMcCTA,并连续注射了加多和含的对比剂.
- 使用SyngoVia软件进行了DECT成像和后处理.
主要成果:
- DECT使用物质分离比率成功地区分了含和加多剂.
- 含的药物隔离了心上血管,而加多的药物特征是心肌 perfusion.
结论:
- 在ex vivo PMcCTA中,DECT可以区分脂友性和水性加多对比剂.
- 这种技术可以同时评估血管通透度和心肌 perfusion 变化.
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