母婴接种疫苗以预防新生儿感染和打击抗菌素耐药性
Eva P Galiza1, Eve Nakebembe2, Robert Mboizi3
1Centre for Neonatal and Paediatric Infection, City St George's, University of London, London, UK.
Seminars in fetal & neonatal medicine
|November 1, 2025
概括
母亲接种疫苗通过转移抗体来保护新生儿,减少感染,降低对抗生素的需求. 这一战略是打击婴儿和母亲抗菌素耐药性的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 孕产妇接种疫苗是新生儿预防传染病的关键策略.
- 被动免疫通过胎盘传递给胎儿,通过母乳传递给婴儿.
- 减少新生儿感染可以减少抗微生物药物的使用,并减缓抗微生物药物耐药性的发展.
研究的目的:
- 突出母亲免疫在预防新生儿感染中的作用.
- 强调母体疫苗接种在减少抗微生物消费和耐药性的潜力.
- 讨论当前和管道中的孕产妇疫苗对抗生素管理的影响.
主要方法:
- 审查证据支持孕产妇接种疫苗预防新生儿感染.
- 分析孕产妇免疫接种对母亲和新生儿抗菌药物使用的影响.
- 对新生儿败血症病原体的管道疫苗潜力的评估.
主要成果:
- 像Tdap,流感,COVID-19和RSV这样的孕产妇疫苗证明了抗生素节约的好处.
- 预防孕产妇和新生儿感染减少了对抗微生物药物治疗的需要.
- 针对B组链球菌,Klebsiella肺炎和大肠杆菌的管道疫苗显示出降低新生儿败血症率的希望.
结论:
- 孕产妇免疫是保护新生儿和减少医疗干预的经过验证的方法.
- 将母体疫苗接种与感染预防和抗生素管理相结合,可以限制围产期的抗生素暴露.
- 孕产妇疫苗接种是一种可扩展和实用的方法来打击抗菌素耐药性.
相关概念视频
Vaccinations
51.2K
Overview
51.2K
Microorganisms in Medicine and Therapeutics
925
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
925
Development of Immunocompetence
781
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
781
Healthcare Associated Infections II: Preventive Measures
3.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.6K
Pneumonia V: Nursing management and Prevention
3.4K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
3.4K
Antimicrobial Effectiveness
894
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
894


