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Updated: Jan 12, 2026

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后COVID-19嗅觉功能障碍中的基因表达和灰色物质体积变化:一项转录基因神经成像研究

Jixin Luan^1,2, Tianyang Li^2,3, Xiaolin Zhou⁴

¹Department of Radiology, China-Japan Friendship Hospital, Beijing, China.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

|November 2, 2025

概括

后COVID-19嗅觉功能障碍 (PCOD) 与大脑变化有关. 脑内皮层灰质体积增加与嗅觉丧失相关,涉及特定基因表达和GABAergic神经元.

科学领域:

神经科学是一个神经科学.
基因组学就是基因组学.
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

后COVID-19嗅觉功能障碍 (PCOD) 是SARS-CoV-2感染的常见后果.
在PCOD患者中观察到结构性大脑变化,但分子机制尚不清楚.

研究的目的:

调查灰质体积 (GMV) 变化和PCOD患者的基因表达模式之间的关系.
确定特定的生物学途径和细胞类型,涉及PCOD的病理生理学.

主要方法:

36名PCOD患者和40名健康对照人接受了嗅觉心理物理测试 (嗅探棒) 和视觉模拟尺度 (VAS) 评估.
在34个大脑区域分析了灰质体积 (GMV).
使用了斯皮尔曼相关性,部分最小平方回归 (PLS) 和基因组丰富分析.

主要成果:

经COD患者表现出脑内皮层的GMV增加,与嗅觉功能的评分 (VAS和Sniffin' Sticks) 有积极的相关性.
PLS分析显示,区域转基因病毒变化与特定基因表达模式之间存在显著的关联.
丰富分析确定了"无机离子跨膜运输"和"蛋白质运输调节"作为关键的生物过程,在GABAergic神经元中具有高基因表达.

结论:

在PCOD中改变的大脑结构与特定的基因表达特征有机械联系.
这些发现强调了无机离子和蛋白质运输通路以及GABAergic神经元在PCOD病理生理学中的作用.
这项研究为COVID-19后嗅觉功能障碍的分子基础提供了新的见解.

关键词:

在 COVID-19 疫情中,细胞解码的细胞解码基因转录基因转录灰色物质体积,灰色物质体积.嗅觉功能障碍嗅觉功能障碍

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