相关实验视频

Updated: May 7, 2026

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Published on: November 4, 2022

在中性粒细胞中暂时弹性的表征

Richard E Waugh¹, Elena Lomakina¹

¹Department of Biomedical Engineering, University of Rochester, Rochester, New York.

Biophysical journal

|November 2, 2025

概括

白细胞的可变性对细胞功能至关重要. 一个新的短暂弹性模型揭示了持续的弹性应力和细胞质粘度,提供了被动中性粒细胞机制的全面描述.

科学领域:

生物物理学的生物物理.
细胞力学细胞力学
类风病学类风病学类风病学

背景情况:

白细胞的可变性对于血管通道和内皮相互作用至关重要,特别是在微血管系统中.
现有的机械模型不够描述细胞的行为,即使在被动状态.

研究的目的:

提供证据,证明细胞在变形过程中对细胞应激产生持续的弹性贡献.
开发和验证基于暂时弹性的细胞行为新模型.
用材料系数来描述被动中性粒细胞的机械性质.

主要方法:

将中性粒细胞变形成圆柱形的管管,以近似细胞力学.
开发一种暂时弹性模型来描述细胞行为.
从细胞变形的实验测量中估计材料系数.

主要成果:

弹性反应表现出应变硬,模拟为一个不可压缩的Gent材料 (弹性模量~28±7Pa).
稳定状态的流量显示了取决于力的应力放松和细胞质粘度 (32.1 ± 0.2 Pa s).
一个压力放松模型确定了网络稳定性和依赖压力的放松率系数.

结论:

新模型全面描述了被动中性粒细胞对强力的机械反应.
这项工作为建模白细胞和类似细胞机制建立了新的范式.
了解这些特性对于预测细胞在生理和病理条件下的行为至关重要.

更多相关视频

Author Spotlight: Quantifying Neutrophil Extracellular Traps in Disease and Drug Screening Using Dual-Color Live-Cell Imaging

Author Spotlight: Quantifying Neutrophil Extracellular Traps in Disease and Drug Screening Using Dual-Color Live-Cell Imaging

Published on: December 1, 2023

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists

Published on: October 18, 2024

相关概念视频

Acute Inflammation I: Cellular Phase

Acute Inflammation I: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...