防止白细胞外流动过程中的血管泄漏的机制
Siem J de Haan1, Jaap D van Buul1,2
1Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Acta physiologica (Oxford, England)
|November 2, 2025
概括
在炎症期间白细胞扩散 (TEM) 并不会直接导致血管泄漏. 有机制限制泄漏,为炎症性疾病提供治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 血管生物学 血管生物学
背景情况:
- 炎症涉及免疫系统对有害刺激的反应.
- 白细胞扩散,或跨内皮细胞迁移 (TEM),是白细胞穿越内皮细胞屏障到受损组织的关键.
研究的目的:
- 为了澄清白细胞TEM和血管泄漏之间的关系.
- 确定在TEM期间防止血管泄漏的机制.
- 探索这些机制对于炎症性疾病的临床相关性.
主要方法:
- 关于白细胞扩散和血管透性的现有文献的综述.
- 对TEM的时空调节和血管泄漏的分析.
- 识别在转化过程中防止血管泄漏的保护机制.
主要成果:
- 白细胞TEM和血管泄漏是不同的,不结合的事件.
- 特定的机制可以在白细胞转移过程中积极防止过度的血管泄漏.
- 了解这些机制对于控制炎症反应至关重要.
结论:
- 总结了在白细胞转移期间限制血管泄漏的机制.
- 强调这些机制对向治疗的临床相关性.
- 提供了关于在炎症条件下控制血管泄漏的见解.
相关概念视频
01:38Inflammation
61.4K
Overview
61.4K
01:16Vascular Spasm
3.2K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
3.2K
01:24Regulation of Angiogenesis and Blood Supply
3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
01:25Selectins
4.1K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
4.1K
01:24Adherens Junctions
6.0K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
Adherens Junctions are Dynamic
6.0K
01:28Inflammatory Response
15.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.8K