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对于空间分成的质子束,二次辐射的剂量分布在水幻体中

A Tobola-Galus¹, L Stolarczyk², I Ambrožová³

¹Institute of Nuclear Physics PAN (IFJ PAN), Radzikowskiego 152, Krakow 31-342, Poland.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

|November 2, 2025

概括

质子疗法中的网格聚合器显著增加散射辐射剂量,与单独的笔束扫描相比,吸收剂量增加了五倍,快速中子增加了十倍. 聚合器是这种二次辐射的主要来源.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
剂量测量方法剂量测量方法

背景情况:

质子疗法利用笔光束扫描 (PBS) 进行精确的剂量递送.
网格聚合器正在探索空间分离质子辐射疗法,可能改变剂量分布.
了解电网聚合器的二次辐射对于患者安全至关重要.

研究的目的:

在质子辐射过程中使用网格聚合器量化水中的3D散射辐射剂量.
为了比较二次剂量从网格聚合器增强的PBS与标准的PBS技术.
评估电网聚合器对患者暴露于马和中子辐射的影响.

主要方法:

在水幻影中使用热发光 (TLD),射电光发光 (RPL) 和轨道探测器 (PADC) 的3D剂量映射.
在EURADOS实验中,在布罗诺维茨的旋中心 (IFJ PAN) 进行辐射.
蒙特卡洛 (MC) 模拟支持了剂量评估.

主要成果:

在近距离光束区域和Spread Out Bragg Peak (SOBP) 中观察到最高的吸收剂量.
与PBS单独相比,使用网格聚合器的PBS导致外场吸收剂量增加了5倍.
快速中子剂量与网格聚合器增加了大约10倍,相当于光子辐射疗法的分散剂量.

结论:

电网聚合器被认为是空间分离质子辐射疗法的马和中子辐射的主要来源.
尽管增加了二次剂量,但网格聚合器被认为是可行的,因为它们可以适应不同的质子疗法系统.
对在质子疗法中使用网格聚合器剂量减轻策略的进一步研究是有必要的.

关键词:

剂量测量方法剂量测量方法模拟MC模拟的MC模拟质子辐射疗法质子辐射疗法二次辐射辐射二次辐射的辐射.空间分成部分的质子束.

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