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在抗NMDAR脑炎的成年患者中,工作记忆期间大脑活动发生变化

Jiajia Zhou¹, Zhongqin Chen¹, Zheng Li²

¹Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Brain and cognition

|November 2, 2025

概括

抗N-甲基-D-酸盐受体 (anti-NMDAR) 脑炎患者的工作记忆缺陷与大脑网络活动的改变有关. 补偿性执行控制网络 (ECN) 过度激活和默认模式网络 (DMN) 停用可能是这些认知障碍的基础.

科学领域:

神经科学是一个神经科学.
认知神经学认知神经学
精神病学是一个精神病学.

背景情况:

在抗N-甲基-D-酸盐受体 (抗NMDAR) 脑炎幸存者中,工作记忆 (WM) 缺陷很常见.
尽管整体临床康复,这些认知障碍仍然存在,影响生活质量.

研究的目的:

为了研究执行控制网络 (ECN) 和默认模式网络 (DMN) 的神经动态,在后急性抗NMDAR脑炎患者中.
为了确定是否改变了网络活动是该患者群体中工作记忆功能障碍的基础.

主要方法:

功能磁共振成像 (fMRI) 用于扫描26名抗NMDAR脑炎患者和23名健康对照 (HC).
在fMRI扫描期间,参与者完成了一项视觉空间的n-back任务,以评估工作记忆.

主要成果:

与HC相比,患者在n-back任务上表现出较低的准确性.
神经成像显示,患者的ECN (额头,运动,部区域) 过度激活,DMN (部,部,副中心区域) 更大程度的失活.
ECN激活与患者的WM表现呈正相关性,这种关系缓冲了小组表现的差异.

结论:

抗NMDAR脑炎中的工作记忆缺陷与补偿性ECN过活化和DMN停活有关.
这些发现表明NMDAR介导网络功能障碍的潜在神经生物标志物,并提供了对认知缺陷的机制性见解.

关键词:

默认模式的网络模式是默认模式.脑炎是一种脑炎.执行控制网络执行控制网络工作记忆工作记忆这是一种抗NMDA受体的药物.功能磁力共振成像 (fMRI) 是一种

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