儿童自闭症特征与青春期白天皮质醇活性之间的关系
Ellie Roberts1, Marta Francesconi2, Eirini Flouri2
1Division of Biosciences, Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK.
Psychoneuroendocrinology
|November 2, 2025
概括
患有持续自闭症特征的自闭症青少年表现出皮质醇唤醒反应 (CAR) 的增加,这是一个压力指标. 这表明局势压力加剧,而不是自闭症青少年普遍的HPA轴功能障碍.
科学领域:
- 神经发育障碍 神经发育障碍
- 内分泌学 在内分泌学.
- 青少年健康 青少年健康
背景情况:
- 自闭症青少年比非自闭症同龄人面临的压力水平更高.
- 慢性压力会影响下丘脑-垂体-上腺 (HPA) 轴,可通过皮质醇测量.
- 关于自闭症青少年皮质醇的先前研究受到横截面设计,小样本和排除女性或被诊断的个体的限制.
研究的目的:
- 为了前性地研究儿童自闭症特征与青少年皮质醇活动之间的联系.
- 调查自闭症特征的严重性和持续性是否与青春期的HPA轴调节相关.
主要方法:
- 利用了915名参与者在阿文长度研究的父母和孩子 (ALSPAC) 的数据.
- 8,11和14岁的相关自闭症特征 (社会沟通障碍检查清单),15岁的四个皮质醇指数.
- 使用回归分析来评估自闭症特征对皮质醇活性的影响,控制混因素.
主要成果:
- 严重和持久的自闭症特征 (可能是自闭症) 与15岁时皮质醇唤醒反应 (CAR) 的增加有关,即使经过混调整.
- 没有发现自闭症特征与日间皮质醇倾斜,早晨的皮质醇总量或每天的皮质醇总量之间有显著的关联.
结论:
- 自闭症特征与CAR相关,但与其他皮质醇指标无关,表明特定的应激反应模式.
- 这表明自闭症青少年在过渡期间情况反应加剧和预期压力,而不是一般化的HPA轴功能障碍.
相关概念视频
Autism Spectrum Disorder
946
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
946
Cognitive Development During Adolescence
485
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
485
Attention-Deficit/Hyperactivity Disorder
733
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
733
Socioemotional Development during Infancy
418
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
Primary Temperament Types
418
Oppositional Defiant Disorder
603
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
603
Conduct Disorder
470
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
470


