尼日利亚儿科人口中的侵入性真菌感染:系统性审查
Glory Bassey1, Mary Alex-Wele2, Usenobong Akpan3
1Department of Paediatrics, University of Calabar, Calabar, Nigeria; Department of Paediatrics, University of Calabar Teaching Hospital, Calabar, Nigeria.
Journal de mycologie medicale
|November 2, 2025
概括
侵袭性真菌感染 (IFI) 对尼日利亚儿童构成严重威胁,侵袭性 кандидоз是最常见的. 诊断和治疗缺陷,包括诊断延迟和缺乏抗真菌药物,导致结果差.
科学领域:
- 儿童传染病 儿童传染病
- 菌类学 菌类学是指菌类学.
- 尼日利亚的公共卫生.
背景情况:
- 侵袭性真菌感染 (IFI) 在所有年龄段构成全球健康负担.
- 虽然尼日利亚的IFI已被研究,但缺乏专注于儿科人口的全面审查.
- 这项研究解决了对尼日利亚儿童FIIs进行系统审查的需要.
研究的目的:
- 系统地审查和综合现有关于尼日利亚儿科人口入侵性真菌感染的文献.
- 确定尼日利亚儿童的IFI类型,诊断方法和结果.
- 突出尼日利亚儿科FIIs诊断和管理的挑战和差距.
主要方法:
- 系统性文献审查遵循系统性审查和元分析 (PRISMA) 准则的首选报告项目.
- 搜索了PubMed的案例报告,案例系列和对尼日利亚儿童的IFI的观察研究,从开始到2024年12月.
- 包括35篇文章,报道了114个国际金融机构的案例.
主要成果:
- 在1964年至2023年期间,共发现了114例儿科IFI病例.
- 侵袭性角膜炎是最常见的 (59.6%),其次是基质质体病 (16.7%) 和肠膜炎 (7.9%).
- 诊断主要依赖于培养 (51.8%) 和组织病理学 (26.3%);20.2%的病例导致死亡,通常与延迟诊断和不充分的抗真菌治疗有关.
结论:
- 在尼日利亚儿童中,侵入性真菌感染的诊断严重不足.
- 关键的管理缺陷包括低怀疑率,延迟诊断,有限的诊断工具 (特别是非培养基测定) 和缺乏抗真菌药物.
- 提高意识,积极监测和有针对性的研究资金对于改善IFI在这个脆弱人群中的结果至关重要.
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