优先考虑的农药的基于风险的排名:当暴露组与比较毒基因组学相符合时
Beibei Gao1, Xu Yang2, Jiawei Duan1
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Environment international
|November 2, 2025
概括
通过吸入灰尘而暴露于农药会对健康造成重大风险,特别是对呼吸系统. 一个新的系统 (RDES) 量化了这些风险,确定了韩国具有最高的基于暴露的健康风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 杀虫剂对农业至关重要,但会污染尘埃,造成人类暴露的途径尚未得到充分研究.
- 吸入灰尘是农药吸收的重要途径,相关的健康风险不明.
研究的目的:
- 开发和应用一个系统来估计通过尿液和尘埃的内部农药暴露.
- 分析粉尘摄入暴露与不同人口和季节的健康风险之间的关联.
- 引入一个框架来评估新出现的污染物和预测健康风险.
主要方法:
- 开发了反向剂量计评估系统 (RDES) 来估计来自尿液 (EDIu) 和尘埃 (EDI d) 的内部暴露.
- 分析了八种关键的农药,具有高尘埃摄入暴露风险.
- 在13个国家利用RDES和数据库 (Tox21,CTD) 进行跨区域分析.
主要成果:
- 鉴定了12个人体系统因摄入农药粉尘而面临的风险.
- 甲和甲暴露与喘,肺损伤,肺纤维化和肺瘤的风险增加有关.
- 在韩国发现的基于暴露的健康风险最高,其次是哥斯达黎加/南非,中国,比利时,波兰和美国.
结论:
- RDES提供了一个标准化框架 (ESIEHR) 来评估新出现的污染物风险.
- 粉尘中的农药污染对健康构成重大,可量化的风险,特别是对呼吸系统.
- 有针对性的干预措施是必要的,以减轻通过吸入灰尘而暴露于农药对健康的影响.
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