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骨关节炎中的循环生物标志物:系统审查揭示了关键趋势和未来前景

Francesca Veronesi¹, Francesca Salamanna¹, Giulia Sacchi¹

¹Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, Bologna 40136, Italy.

Pathology, research and practice

|November 2, 2025

概括

循环中的蛋白质和微RNA显示为诊断骨关节炎 (OA) 和监测其进展的非侵入性生物标志物具有前途. 这些分子与炎症和软骨损伤有关,这表明OA的潜在治疗点.

科学领域:

生物化学生物化学
分子生物学分子生物学
类风湿病学类风湿病学

背景情况:

骨关节炎 (OA) 是一种退行性关节疾病,导致疼痛和运动能力下降.
由于缺乏特定的生物标志物,OA的早期诊断和监测具有挑战性.
包括蛋白质和微RNA (miRNAs) 在内的循环生物标志物正在被研究用于OA管理.

研究的目的:

系统地审查循环中的蛋白质和miRNA生物标志物,以确定它们在OA中的诊断和预后潜力.
为了确定与OA病变发生相关的分子表型.

主要方法:

在PubMed,科学网和Scopus (2015年3月至2025年3月) 的系统文献搜索.
包括18项临床研究 (12项针对蛋白质,6项针对miRNAs).
使用STRING和miRNet工具进行功能网络分析.

主要成果:

几种血清蛋白质 (例如IL-6,C3,ATX,PTX3,HA,CLU) 在OA患者中升高,与疾病严重程度相关.
特定的miRNA被发现在OA中处于下调 (例如let-7e) 或上调 (例如miR-146a-5p) 状态.
生物标志物通过炎症和软骨路径参与了OA的发病.

结论:

循环中的蛋白质和miRNAs是膝关节OA的有希望的非侵入性生物标志物.
确定了两个主要的分子表型:炎症代谢和软骨转换轴.
为了临床整合,还需要进一步的大规模,标准化的研究.

关键词:

循环生物标志物循环生物标志物在循环中的miRNA.循环蛋白质是循环中的蛋白质.临床观点临床观点骨关节炎是一种骨关节炎.系统性审查系统性审查

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