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生殖状况影响男性和女性的压力诱导的荷尔蒙和免疫变化Rhinella diptycha
Stefanny Christie Monteiro Titon1, Braz Titon Junior1, Vania Regina Assis2
1Departamento de Fisiologia - Instituto de Biociências, Universidade de São Paulo, Rua do Matão, trav. 14, 101, 05508-090 São Paulo, SP, Brazil.
General and comparative endocrinology
|November 2, 2025
概括
急性压力迅速增加的皮质,影响生殖荷尔蒙和免疫功能. 长期的压力抑制性类固醇,改变免疫反应,可能受到生殖行为的影响.
科学领域:
- 动物学 动物学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 物种的季节性繁殖涉及显著的生理变化,包括生殖和免疫功能.
- 通过葡萄糖皮质激素介导的应激反应对于在不可预测事件期间平衡生存和繁殖至关重要.
- 了解压力对两生物内分泌和免疫系统的影响至关重要,尤其是在生殖期间.
研究的目的:
- 为了研究急性抑制应激对雄性和雌性 (Rhinella diptycha) 生殖期间内分泌和免疫参数的影响.
- 评估压力后血激素水平 (皮质,,雌激素) 和免疫措施 (杀死细菌的能力,中性粒细胞与淋巴细胞的比率) 的变化.
- 探索生殖行为 (呼叫与寻找食物) 如何影响压力诱导的生理变化.
主要方法:
- 现场捕获的雄性和雌性Rhinella diptycha被接受了克制方案,在0,1和24小时取血样.
- 测量了皮质,和雌激素的血水平.
- 血杀死细菌的能力和中性粒细胞与淋巴细胞的比率被评估为免疫功能的指标.
主要成果:
- 血皮质水平在克制后1小时和24小时显著增加,无论男女.
- 雌激素和丸激素水平在禁食后24小时下降,不论性别或活动.
- 杀死细菌的能力在1小时内在呼叫雄性中呈现暂时的增加,但在24小时内在所有中下降.
- 中性粒细胞与淋巴细胞的比率在禁食24小时后在寻食的雄性中增加.
结论:
- 急性压力会引起的快速和持续的皮质反应.
- 长时间的压力导致性类固醇的抑制,并调节免疫功能.
- 压力诱导的免疫调节似乎受到的繁殖行为的影响,在召唤与寻找食物的雄性中观察到不同的效果.
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