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孕妇X受体激活调节粉样蛋白的运输,以改善阿尔茨海默病的认知功能

Tiancheng Gu1, Shaoheng Ma2, Wei Liu1

  • 1Department of Clinical Pharmacy, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.

European journal of pharmacology
|November 2, 2025
PubMed
概括

孕妇X受体 (PXR) 激活显示出阿尔茨海默病 (AD) 治疗的前景. 在小鼠模型中激活PXR改善了认知功能并减少了粉样蛋白斑块,这表明了治疗潜力.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.超级氨酸 (Hyperforin) 是一种药物.低密度脂蛋白受体相关蛋白1 (LRP1) 是一种低密度脂蛋白受体相关蛋白.这是一种P-glycoprotein蛋白.孕妇的X受体受体.

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