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双化合物对内分泌干扰和生殖功能的影响,从流行病学分析到动物暴露:混合物分析

Peiyun Jiang¹, Weiwei Wang², Jiande Li²

¹Department of Environmental Health, School of Public Health, Center for Ecological Public Health Security of Yellow River Basin, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China; Liangping District Center for Disease Control and Prevention, Chongqing 405299, China.

Journal of environmental sciences (China)

|November 2, 2025

概括

暴露于双A (BPA) 和其替代品双F (BPF) 和双S (BPS) 的混合物会扰乱小鼠的激素水平并损害生殖功能. 这强调了需要评估化学混合物,而不仅仅是单个化合物,以进行准确的风险评估.

科学领域:

环境毒理学环境毒理学
内分泌学在内分泌学.
生殖生物学生殖生物学

背景情况:

双A (BPA) 替代物,如双F (BPF) 和双S (BPS) 可能具有类似的内分泌干扰特性.
当前的化学风险评估往往忽视了化学混合物的综合作用.

研究的目的:

研究BPA,BPF和BPS单独或混合的内分泌干扰作用.
评估这些双醇对类固醇激素平衡和生殖系统功能的影响.

主要方法:

动物研究涉及四周内每天对雌性和雄性小鼠暴露于BPA,BPF,BPS及其混合物 (MIXL,MIXH).
与类固醇激素合成相关的基因表达的分析.
测量血清激素水平 (雌激素,孕激素,丸激素).
生殖器官的组织病理学检查和精子质量的评估.
基于人群的调查,以证实动物研究的结果.

主要成果:

双暴露影响了参与类固醇激素合成的基因.
在雌性小鼠中,混合暴露显示了雌激素,孕和水平的变化趋势,以及动脉囊的增加.
在雄性小鼠中,混合暴露导致雌激醇增加,丸形态受损,精子质量降低.
流行病学数据证实了双暴露与激素水平变化之间的相关联系.

结论:

对双醇的混合暴露显著破坏激素水平,并对动物模型中的生殖功能产生不利影响.
流行病学证据支持双暴露与人类人群中的荷尔蒙失衡之间的联系.
风险评估策略必须包括对化学混合物的评估,以准确反映现实中的暴露场景.

关键词:

动物实验动物实验双醇是一种双醇.流行病学研究是流行病学研究.混合物暴露混合物暴露生殖功能生殖功能.类固醇激素合成的合成

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