血性淋巴瘤与血管内定位在卡波西肉瘤皮肤损伤皮肤损伤
Mercedes Sanchez-Diaz1, Daniel La Rosa2, Bruner García3
1Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Journal of cutaneous pathology
|November 2, 2025
概括
这种罕见的病例突显了艾滋病毒阳性患者的等离子体淋巴瘤 (PBL). 在卡波西肉瘤 (KS) 病变中发现了血管内PBL细胞,这表明异常的疾病传播.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 血性淋巴瘤 (PBL) 是一种侵略性的非霍奇金淋巴瘤.
- 它主要影响艾滋病毒阳性个体,经常涉及口腔或外节.
- 卡波西肉瘤 (KS) 是一种常见的HIV相关恶性瘤,由HHV-8引起.
研究的目的:
- 报告一种罕见的PBL呈现.
- 描述PBL和KS在HIV阳性患者中的共存.
- 为了调查在KS病变中异常发现血管内PBL细胞.
主要方法:
- 病例报告和临床数据审查.
- 淋巴结,胃和皮肤活检样本的组织病理学检查.
- 免疫组织化学分析以确认细胞系和标记物.
主要成果:
- 诊断血性淋巴瘤的结节和胃的参与.
- 在先前存在的卡波西肉瘤皮肤病变中识别血管内PBL细胞.
- 两种不同的艾滋病毒相关恶性瘤的同时发生.
结论:
- 这一案例强调了PBL在HIV阳性个体中的多样性和攻击性.
- 在KS中存在血管内PBL细胞表明传播的潜在途径.
- 需要进一步的研究,以了解PBL和KS在HIV感染的背景下之间的相互作用.
相关概念视频
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Blood and Nerve Supply to the Bones
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...


