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骨质疏松症和大动脉狭窄症之间共享的分子机制的综合生物信息分析

Yue-Jiao Yang¹, Yang He¹, Zhao-Wei Zhu¹

¹Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, China.

Current medicinal chemistry

|November 2, 2025

概括

这项研究确定了关键基因CD4,GZMB和SDC1,将骨质疏松症与大动脉狭窄症联系起来. 这些发现揭示了这些常见的与年龄有关的疾病的共享免疫和炎症途径,提供了潜在的治疗点.

科学领域:

基因组学就是基因组学.
生物信息学是一种生物信息学.
免疫学免疫学免疫学

背景情况:

骨质疏松症 (OP) 和大动脉狭窄症 (AS) 是常见的与年龄相关的疾病,经常共存.
骨血管轴连接OP和AS的分子机制尚不清楚.

研究的目的:

确定共同的基因和途径,有助于OP和AS的并发症.
探索骨血管轴的分子基础.

主要方法:

在公开的转录基因数据集上利用了权重基因共同表达网络分析 (WGCNA) 和差异基因表达 (DEG).
进行了蛋白质与蛋白质相互作用 (PPI) 网络分析,并与比较毒基因组学数据库 (CTD) 集成数据.
在独立队列中验证了候选基因,并使用LASSO回归评估了诊断潜力.

主要成果:

鉴定了665个共同的基因,富含免疫,炎症,细胞粘附和糖氨基甘氨酸生物合成途径.
确定了15个高度信任的基因,其中CD4,GZMB和SDC1被证实在AS和OP中失调.
证明了这些基因的高诊断准确性,AUC总值为0.94.

结论:

免疫和炎症途径是AS和OP病变发生的融合机制.
已识别的枢纽基因 (CD4,GZMB,SDC1) 参与免疫调节和细胞外矩阵重塑.
CD4,GZMB和SDC1作为关键基因,将OP和AS联系起来,呈现出潜在的生物标志物和治疗点.

关键词:

CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 石大动脉狭窄症石大动脉狭窄症这是GZMB.在SDC1中,SDC1是SDC1.生物信息学是一种生物信息学.骨质疏松症是一种骨质疏松症.

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