关于固体瘤瘤微环境中的内部和外部因素相互作用的新进展
Cong Zhang1,2, Qian Sun1,2
1National Clinical Research Center for Obstetrics and Gynecology, Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Expert review of clinical immunology
|November 3, 2025
概括
了解瘤微环境对于有效的癌症免疫疗法至关重要. 这篇评论探讨了瘤免疫逃生,代谢重编程和神经免疫,以推进固体瘤的组合免疫疗法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 瘤微环境 (TME) 是一个复杂的生态系统,影响瘤的进展,入侵和转移.
- 目前的免疫疗法,如免疫检查点抑制剂,CAR T细胞疗法,瘤病毒和双特异性抗体,旨在调节TME内的抗瘤免疫反应.
- 克服TME带来的挑战对于提高固体瘤免疫疗法的疗效至关重要.
研究的目的:
- 审查了解瘤免疫逃生,代谢重编程和神经免疫的最新进展.
- 分析这些生物过程对抗瘤免疫力的影响.
- 通过整合基础科学和临床试验设计,确定对固体瘤的潜在组合免疫疗法策略.
主要方法:
- 从2000年到2025年5月21日,在PubMed数据库中发表的研究文献综述.
- 对专注于瘤免疫逃脱,代谢重编程和神经免疫力的研究进行分析.
- 综合发现,为设计新型组合免疫疗法提供信息.
主要成果:
- 新兴的单细胞测序和空间瘤技术正在揭示TME内的细胞相互作用的复杂细节.
- 对瘤免疫逃生机制,代谢重编程和神经免疫交叉通话的洞察力为治疗干预提供了新的目标.
- 该审查巩固了有关主要免疫疗法及其与TME相互作用的当前知识.
结论:
- 更深入地了解TME的复杂性,包括免疫逃脱,新陈代谢和神经免疫,对于推进癌症免疫疗法至关重要.
- 结合基础研究和临床研究的发现,可以指导制定有效的组合治疗计划.
- 这项研究旨在为克服固体瘤免疫治疗中与TME相关的障碍提供一个框架.
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