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通过激活 IRE1 来改善 GABAA受体变体的蛋白质稳定性

Xu Fu1, Ya-Juan Wang1, KyungA Lee2

  • 1Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.

ACS chemical neuroscience
|November 3, 2025
PubMed
概括

IRE1/XBP1s通路的药理激活改善了模型中的GABAAR贩运. 这种方法增强了受体表面表达和功能,为遗传性提供了潜在的治疗方法.

关键词:
在GABAA受体中,GABAA受体具有爱尔兰的第一名.是一种.错误折叠 错误折叠 错误折叠 错误折叠蛋白质稳定症是一种蛋白质稳定症.蛋白质稳定调节剂 蛋白质稳定调节剂

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