富含SCFA的基维果衍生的共生生物重新编程微生物群以抑制XOD并促进尿液清除
Qianxu Wang1,2, Xiaoping Pu1,3, Yi Song1
1College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
一种含有Lactiplantibacillus plantarum LP220的新奇基维果协生菌有效降低了小鼠的高尿血症 (HUA). 这种以植物为基础的方法可以增加有益的短链脂肪酸 (SCFA),并恢复肠道健康.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 肠道功能失调与高尿血 (HUA) 有关.
- 增强短链脂肪酸 (SCFA) 的植物性协生菌对HUA没有得到充分的研究.
- 益生菌和益生菌可以调节肠道微生物群的组成和功能.
研究的目的:
- 为了研究果衍生的协生菌 (Lactiplantibacillus plantarum LP220 + 果粉) 在管理高尿血症 (HUA) 的有效性.
- 探索潜在的机制,包括SCFA生产和肠道微生物群调节.
主要方法:
- 在体外评估LP220的SCFA生产.
- 在体内研究,使用腺素和氧酸盐诱导的HUA小鼠模型.
- 对血清尿酸,SCFA水平,炎症标志物,肠道微生物群组成和基因表达 (丁氧化酶,ABCG2) 的分析.
主要成果:
- 与对照组,LP220或单独使用基维果相比,协生菌显著降低了HUA小鼠的血清尿酸水平.
- 同生菌治疗增加了便和血清 propionate 和酸盐水平,表明SCFA的产量增加.
- 观察到系统性炎症 (LPS,IL-1β) 减少,肝脏桑氧化酶活性降低,ABCG2表达升调.
- 肠道微生物多样性得到恢复,SCFA生产细菌的丰富.
结论:
- 这种基维果衍生的协生生物有效地抑制尿酸合成,并促进尿酸在HUA中的分泌.
- SCFA 生产和微生物群与宿主相互作用是共生菌有效性的关键机制.
- 这种共生菌代表了一种有前途的向微生物群的营养策略,用于管理高尿路血症.
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