抑郁症患者吸烟状况的变化和痴呆症的风险
Yoo Jin Jang1, Hyewon Kim2, Jin-Hyung Jung3
1Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul.
The Journal of nervous and mental disease
|November 3, 2025
概括
在抑郁症诊断后继续吸烟显著增加痴呆症的风险,包括阿尔茨海默病和血管痴呆症. 戒烟降低了风险,但仍然高于从未吸烟的人,强调了需要戒烟支持的需要.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 吸烟是已知的痴呆症风险因素之一.
- 吸烟行为改变后抑郁症诊断对痴呆风险的影响尚不清楚.
研究的目的:
- 调查抑郁症诊断后吸烟行为变化与随后痴呆症风险之间的关联.
- 区分阿尔茨海默病 (AD) 和血管痴呆症 (VD) 的风险.
主要方法:
- 在韩国 (2009-2012) 接受1,290,530名被诊断患有抑郁症的个人的全国性队列研究.
- 参与者按诊断前和诊断后的吸烟状态进行分类.
- 追踪到2018年的事件痴呆症 (AD和VD).
- 使用考克斯模型计算的调整危险比率 (HRs).
主要成果:
- 持续吸烟后的抑郁症诊断显示出痴呆的风险最高 (所有原因HR 1.338,ADHR 1.323,VDHR 1.524).
- 与继续吸烟相比,戒烟降低了痴呆症的风险,但风险仍然高,而不是持续的非吸烟者.
- 中年被确定为阿尔茨海默病风险的关键时期.
- 男人始终表现出更高的静脉疾病风险;女性表现出更高的静脉疾病风险,特别是在戒烟组.
结论:
- 在抑郁症诊断后改变吸烟习惯会影响痴呆症的风险.
- 公共卫生战略应优先考虑抑郁症患者的戒烟干预措施,以减轻痴呆症风险.
相关概念视频
Stress Prevention and Stress Management Techniques IV
221
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
221
Dementia
508
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
508
Stress and Mental Health
625
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
625
Depressive Disorders: MDD and Dysthymia
615
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
615
Psychoneuroimmunology: Diabetes and Cancer
427
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
427
CNS Depressants: Alcohol and Nicotine
1.0K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.0K


