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异常性正常压力脑水性病的临床和放射性演变:一个批判性审查

David Campo-Caballero^1,2, Elissa Ash^3,4, Alfonso Fasano^5,6

¹Department of Neurology, Movement Disorders Unit, Hospital Universitario Donostia, San Sebastián, Spain.

Movement disorders clinical practice

|November 3, 2025

概括

异常性正常压力脑症 (iNPH) 异质地演变,步态障碍最早出现. 确定临床前iNPH阶段对于有效的治疗结果评估至关重要.

科学领域:

神经学神经学
神经外科神经外科
老年病的医生老年病的医生

背景情况:

异常性正常压力头症 (iNPH) 的病理生理学尚未完全理解.
临床前和iNPH发展的早期阶段在很大程度上是未知的.
了解iNPH演变对于患者管理至关重要.

研究的目的:

调查iNPH的临床和放射性表现.
了解非转移iNPH患者主要临床症状的演变.
为了深入了解iNPH的自然历史.

主要方法:

关于iNPH的演变的批判性文献综述.
搜索详细描述早期临床特征和症状进展的手稿.
基于临床和放射学发现的文献分类.

主要成果:

走路障碍是iNPH最早的临床症状.
认知障碍有所变化,受伴随疾病的影响;尿路功能障碍从急性发展到失禁.
腹腔扩大等放射性特征在临床前存在,但它们的序列和白质病变的影响尚不清楚.

结论:

iNPH进化表现出显著的异质性.
定义不同的临床阶段和确定临床前iNPH是必不可少的.
治疗结果的评估必须考虑到干预时的疾病阶段.

关键词:

认知障碍是一种认知障碍.批判性审查批判性审查批判性审查走路的干扰走路的干扰异常性正常压力水脑.尿路功能障碍尿路功能障碍

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