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纽卡斯尔病病毒亚基因型VII.1.1在伊朗的演变,2017-2024年

Fereshteh Sabouri¹, Tae-Hyeon Kim², Mohammad Abdoshah¹

¹Department of Avian Disease Research and Diagnostics, Agricultural Research Education and Extension Organization (AREEO), Razi Vaccine and Serum Research Institute, Karaj, Iran.

Avian pathology : journal of the W.V.P.A

|November 3, 2025

概括

纽卡斯尔病病毒 (NDV) 亚基因型VII.1.1自其引入以来,在伊朗独立进化. 持续监测对于监测病毒演变和保护家禽行业免受这种毒性菌株的影响至关重要.

科学领域:

兽医病毒学兽医病毒学
进化生物学进化生物学
禽类的健康禽类的健康

背景情况:

纽卡斯尔病 (ND) 对伊朗的家禽产业构成重大威胁.
纽卡斯尔病病毒 (NDV) 的亚基因型VII.1.1是伊朗流传的主要菌株.
了解NDV演变对于疾病管理至关重要.

研究的目的:

为了调查伊朗NDV的进化动态.
对从家禽和野生鸟类中分离出来的NDV菌株进行遗传学分析.
为了确定占主导地位的NDV亚基因型的起源和进化速度.

主要方法:

60个NDV分离物 (2017-2024) 的基因组测序.
使用最大概率和贝叶斯方法对融合 (F) 和血凝素-神经aminidase (HN) 基因进行基因分析.
进化速率和分歧时间的估计.

主要成果:

所有分析的病毒都属于亚基因型VII.1.1,形成单种群.
在F (>97%) 和HN (>93%) 基因中观察到高序列相同性.
确定了具有特定多基分裂部位的病毒性NDV菌株;进化率为1.31×10−3 (F) 和9.62×10−4 (HN) 替代/部位/年.
最新的共同祖先可以追溯到2007年,可能起源于中东.
病毒多样性在2020年至2024年之间呈指数级增长.

结论:

在伊朗,NDV亚基因型VII.1.1已经独立进化.
在家禽和野生鸟类中对NDV的持续监测对于跟踪演变和减轻威胁至关重要.
了解病毒进化有助于保护家禽的健康和生产.

关键词:

纽卡斯尔病病毒的病毒.奥尔托瓦维拉病毒 javaenseense 进化分析是一种进化分析.遗传学分析遗传学分析类家禽类家禽亚基因型VII.1.11.1 亚基因型VII.1.1 亚基因型

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