通过提升甘油三糖指数的导出和验证,改善心血管风险分层
Georgios Mavraganis1, Georgios Georgiopoulos1,2, Stavros Athanasopoulos1
1Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Diabetes, obesity & metabolism
|November 3, 2025
概括
甘油三糖 (TyG) 指数显示与动脉样硬化心血管疾病 (ASCVD) 事件有显著的关联. 8.46或更高的TyG指数可能会提高初级预防策略中的风险评估.
科学领域:
- 心血管医学 心血管医学
- 代谢综合征研究 代谢综合征研究
- 生物标志物发现发现
背景情况:
- 甘油三糖 (TyG) 指数是动脉样硬化心血管疾病 (ASCVD) 的新兴生物标志物.
- 需要临床验证和确定TyG指数的预后切断值,以整合初级预防.
研究的目的:
- 评估TyG指数在一般人群中的临床适用性和预后价值.
- 为了推导和验证TyG指数的最佳预后切断值.
- 评估TyG指数与亚临床动脉损伤和动脉样硬化进展的相关性.
主要方法:
- 使用ATTICA队列 (n=1677) 进行导出和初级预防队列 (n=1237) 进行外部验证.
- 将主要终点定义为心血管死亡率,心肌梗塞,冠状动脉再血管化或中风的复合.
- 分析了来自雅典心脏代谢队列的1170名患者,以评估亚临床动脉损伤和动脉样硬化进展.
主要成果:
- TyG指数独立地与心血管疾病 (CVD) 事件的增加有关 (HR=1.33,p=0.020).
- 8.46的最佳TyG截止值显示了SCORE2的增量值,由净重新分类指数和Harrell's C指数证实.
- 提升的TyG指数与更多患病的血管床相关 (OR=2.00),亚临床性动脉动脉样硬化进展 (OR=2.99) 和确定的ASCVD.
结论:
- 泰格指数与亚临床和明显ASCVD的更高的患病率和进展有关.
- 在接受初级预防评估的人群中,TyG指数值≥8.46可以作为风险增强剂.
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