最近发病和慢性精神分裂症中的结构性大脑变异性:基于人与人相似度指数分析的证据
Young Tak Jo1, Jungsun Lee2, Sun Min Kim2
1Department of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Acta neuropsychiatrica
|November 3, 2025
概括
与健康个体相比,精神分裂症患者表现出显著的大脑结构差异,甚至在疾病的早期. 基于人格的相似性指数 (PBSI) 强调了这种异质性,尽管其临床关联需要进一步研究.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 大脑结构分析 分析大脑结构
背景情况:
- 在精神分裂症中,结构性脑部异常很常见,但个体的变异性阻碍了生物标志物识别.
- 基于人格的相似性指数 (PBSI) 衡量结构变异性,但其在精神分裂症各个阶段的使用尚未确立.
研究的目的:
- 为了比较皮层和皮层下结构变异性使用PBSI在近期发病和慢性精神分裂症.
- 探索PBSI得分和精神分裂症的临床措施之间的关系.
主要方法:
- 来自41名近期出现的精神分裂症,32名慢性精神分裂症和59名健康对照者的神经成像数据.
- 用皮层厚度,表面积,灰质体积和皮层下体积计算的PBSI.
- 使用线性回归和ANOVA评估PBSI中的群体差异;检查与临床措施的相关性.
主要成果:
- 这两组患者的PBSI得分明显低于对照组,表明结构异质性更大.
- 最近发病的精神分裂症和慢性精神分裂症之间的PBSI差异主要是皮层下和皮层厚度.
- PBSI和临床症状之间的相关性是有限的,主要涉及最近出现的精神分裂症的表面积变化.
结论:
- 精神分裂症的特点是显著的结构性大脑异质性,即使在早期阶段也可以检测到.
- 虽然患者群体之间的差异和与临床措施的相关性是有限的,但PBSI可能会提供对精神分裂症个体差异的见解.
- 在理解精神分裂症的临床异质性方面,PBSI可能是有价值的.
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