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设计,合成和药理学评估核心环扩展芬太尼类同类作为潜在的对抗芬太尼诱导的呼吸系统抑郁的药物

Abeje A Silte1, Ennian Li1, Balaji S Kale1

  • 1Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.

Journal of medicinal chemistry
|November 3, 2025
PubMed
概括

研究人员通过扩大核心环结构开发了新的芬太尼类型. 化合物53有效地逆转了芬太尼引起的呼吸抑制,为合成阿片类药物过量治疗提供了潜在的治疗方法.

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