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可切除肝细胞癌的新辅助免疫疗法:对当前证据的元分析

Ottavia Cicerone¹, Barbara Oliviero², Stefania Mantovani²

¹Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia 27100, Italy.

World journal of clinical oncology

|November 3, 2025

概括

新辅助免疫疗法对可切除的肝细胞癌 (HCC) 是有前途的,提供中度病理反应和高切除率. 这种方法是可行的和安全的,改善了肝癌患者的治疗结果.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
肝细胞癌研究肝细胞癌研究

背景情况:

肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
高复发率限制了HCC肝切除后的长期结果.
新辅助免疫疗法对可切除的HCC的疗效正在积极研究中.

研究的目的:

评估新辅助免疫疗法的疗效,可行性和安全性,用于切除的HCC.
进行对现有关于HCC新辅助免疫治疗的研究进行元分析.

主要方法:

在主要数据库 (PubMed, Web of Science, EMBASE, Cochrane, Scopus) 进行系统的文献搜索,寻找过去五年内的研究.
包括评估新辅助免疫疗法的研究在可切除的HCC.
主要终点的元分析:主要病理反应 (MPR),病理完整反应 (pCR),整体反应率 (ORR),切除率和3-4级治疗相关不良事件 (TRAE).

主要成果:

对12项研究进行了聚合分析.
实现了19%的MPR,35%的ORR和22%的pCR.
证明了81%的切除可行性,严重的 (三至四级) TRAE发生率为19%.

结论:

新辅助免疫疗法是一种可行且安全的策略,用于切除的HCC.
这种方法产生了中度的病理反应.
在HCC患者中,通过新辅助免疫疗法可以实现高切除率.

关键词:

肝细胞癌是肝细胞癌.免疫检查点抑制剂免疫检查点抑制剂切除肝脏切除切除肝脏切除新辅助免疫疗法新辅助免疫疗法在手术前进行治疗.可以切除的肝细胞癌.

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