与腹腔大动脉瘤风险相关的饮食炎症潜力,遗传易感性和全身炎症指数:一个前性队列研究
Duoliang Wei1, Yongliang Zhong1, Xinyi Liu1
1Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.
Frontiers in nutrition
|November 3, 2025
概括
饮食性炎症和遗传风险都会增加腹腔大动脉瘤 (AAA) 的风险. 系统性炎症反应指数 (SIRI) 调解了这一关联,建议综合预防策略.
科学领域:
- 心血管研究研究心血管研究
- 遗传学和流行病学
- 营养科学 营养科学
背景情况:
- 腹腔大动脉动脉瘤 (AAA) 的发病包括慢性炎症和遗传因素.
- 关于饮食炎症对AAA风险的影响的证据有限.
- 这项研究调查了与AAA发病率相关的饮食炎症潜力,遗传易感性和全身炎症.
研究的目的:
- 为了检查饮食炎症潜力和AAA风险之间的关联.
- 评估饮食炎症和遗传易感性对AAA发病率的综合影响.
- 评估系统性炎症指数在饮食与AAA关系中的调解作用.
主要方法:
- 对142,862名英国生物库参与者的前性队列研究,追踪时间为13.8年.
- 使用能量调整的饮食炎症指数 (E-DII) 评估的饮食炎症潜力.
- 基因易感性量化使用多基因风险评分 (PRS);系统性炎症通过SIRI,PNI和控制营养状况评分进行评估.
主要成果:
- 较高的E-DII分数与AAA风险增加相关 (HR:1.36).
- 高PRS和高E-DII的个体显示AAA风险显著增加 (HR:3.04).
- 系统性炎症反应指数 (SIRI) 介导了9.16%的饮食炎症和AAA之间的关联.
结论:
- 饮食的炎症潜力和遗传易感性独立地与更高的AAA风险相关.
- 在将饮食性炎症与AAA联系起来的途径中,SIRI起到关键的调解作用.
- 研究结果支持将饮食策略,遗传查和炎症生物标志物整合为AAA预防.
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