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产前和产后营养对后代疼痛调节和应激反应的影响
Federica Cernigliaro1, Vincenzo Raieli2, Edvige Correnti2
1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialities "G. D'Alessandro", University of Palermo, Palermo, Italy.
Frontiers in nutrition
|November 3, 2025
概括
孕产妇和早期营养通过影响疼痛调节和应激反应,显著影响后代的健康. 对肠-大脑轴的营养影响和表观遗传学可以增加对各种疾病的易感性.
科学领域:
- 营养科学 营养科学
- 发展生物学 发展生物学
- 神经科学是一个神经科学.
背景情况:
- 营养是影响疾病倾向的关键环境因素.
- 早期营养,特别是产前营养,会影响胎儿的生长和大脑发育.
- 以前的研究将产前营养与神经发育障碍联系起来.
研究的目的:
- 审查产前和产后营养对疼痛调节和应激反应的影响.
- 探索这些营养效应背后的机制.
- 确定研究缺口和未来方向.
主要方法:
- 现有文献的叙述性审查.
- 搜索了PubMed和谷歌学者使用关键词,如"产前营养和疼痛调节".
- 精选的主要评论和被排除的个别案例研究.
主要成果:
- 产前和产后营养会影响疼痛和压力反应路径.
- 机制包括下丘脑-垂体-上腺 (HPA) 轴活动,肠-大脑轴,以及表观遗传变化.
- 母亲的饮食会影响基因表达,大脑刺激性,神经递质和神经.
结论:
- 早期的营养对后代的健康产生深远的影响,不仅仅是神经发育.
- 需要进一步研究这些变化的病理生理学.
- 了解这些机制可以指导改善母婴和早期营养的干预措施.
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