不是你平常的罪祸首:复发的沙门氏菌进入血清婴儿尿道感染
Tania Islam1, Darshana Wickramasinghe2, Usman Ul Haq1
1Internal Medicine, Medway NHS Foundation Trust, Gillingham, GBR.
Cureus
|November 3, 2025
概括
沙门氏菌造成的反复性尿路感染 (UTI) 是罕见的,特别是在免疫功能低下的患者中. 基因组分析证实了肠道殖民的复发,通过抗生素和改善物卫生来实现解决.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 尿路感染 (UTI) 是常见的,但由*Salmonella enterica*血清婴儿菌 (S. Infantis) 引起的异常罕见.
- 主体的脆弱性,如转移性癌,糖尿病,慢性病和脊髓切除术,通常与不寻常的尿路病原体感染有关.
研究的目的:
- 报告一个罕见的复发性S. Infantis尿道感染病例,该病例发生在患有多种并发症的患者身上.
- 通过全基因组测序来调查S. Infantis的来源和持续性.
- 描述持续性S. Infantis尿路感染的成功治疗策略.
主要方法:
- 一个60多岁的女性的病例报告,患有多种并发症,经历了反复的尿路感染.
- 重复培养尿液以确定病原体.
- 全基因组测序 (WGS) 用于确认细菌身份并追踪分离物之间的遗传相关性.
- 临床管理包括连续的抗生素疗程和卫生干预措施.
主要成果:
- 该患者在一年内经历了三次S. Infantis尿道感染.
- 世卫组织证实,复发性感染是持续肠道殖民的复发.
- 一个为期七天的抗生素治疗方案与加强物相关的卫生措施相结合,导致持续的尿路感染解决.
结论:
- 这一案例强调了在患有重大并发病症的患者中考虑S. Infantis等不寻常的泌尿病原体的重要性.
- 基因组工具对于确认持续性和确定复发性感染的来源至关重要.
- 解决潜在的动物传染病库,如物,并实施适当的卫生措施对于管理这种病例至关重要.
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