系统性炎症是口腔微生物组和口腔状细胞癌之间缺失的联系吗? 多学科整合分析的结果
Lingjun Yan1, Baochang He2,3, Qingrong Deng4
1Department of Neurosurgery, Neurosurgery Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Journal of oral microbiology
|November 3, 2025
概括
由IL-22和CCL5等细胞因子驱动的全身性炎症将口腔细菌与口腔状细胞癌 (OSCC) 联系起来. 这一发现为OSCC预防和早期检测策略提供了新的途径.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 口腔微生物组,全身炎症和OSCC发展之间的相互作用尚未完全理解.
研究的目的:
- 调查系统性炎症在口腔微生物组变化和OSCC之间的关联中扮演的调解角色.
- 为了确定潜在的微生物和炎症生物标志物用于OSCC诊断和风险评估.
主要方法:
- 从唾液和血细胞因子概况中整合了多种基因组数据.
- 机器学习模型的应用用于微生物标记物识别.
- 调解分析,以评估炎症的作用.
主要成果:
- 在OSCC患者中,口腔微生物的多样性发生了变化,并丰富了特定的细菌,如*金黄色葡萄球菌*,*黑血球菌*和*链球菌*物种.
- 在OSCC患者中观察到九种循环细胞因子的水平升高,包括IL-22和CCL5.
- IL-22和CCL5部分调解了特定口腔细菌与OSCC风险之间的联系.
结论:
- 通过IL-22和CCL5介导的全身炎症是口腔失生症和OSCC之间的关键联系.
- 这些发现突出了OSCC预防和早期干预的潜在治疗目标和诊断策略.
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